Case ID: 564

Publication date: 11 Jan, 2016

Consensus grade: WHO/ISUP grade 3

User Diagnosis Difficulty Comment
Pathologist 1 WHO/ISUP grade 3 Typical
Pathologist 2 WHO/ISUP grade 3 Typical
Pathologist 3 WHO/ISUP grade 3 Typical
Pathologist 4 WHO/ISUP grade 3 Typical
Pathologist 5 WHO/ISUP grade 3 Typical
Pathologist 6 WHO/ISUP grade 3 Typical
Pathologist 7 WHO/ISUP grade 3 Typical
Pathologist 8 WHO/ISUP grade 3 Typical
Pathologist 9 WHO/ISUP grade 3 Typical
Pathologist 10 WHO/ISUP grade 3 Typical
Pathologist 11 WHO/ISUP grade 3 Typical
Pathologist 12 WHO/ISUP grade 3 Typical
Pathologist 13 WHO/ISUP grade 3 Typical
Pathologist 14 WHO/ISUP grade 3 Typical
Pathologist 15 WHO/ISUP grade 3 Typical
Pathologist 16 WHO/ISUP grade 2 Borderline higher
Pathologist 17 WHO/ISUP grade 3 Typical


Case description (by case creator):

Incidentally found 1.9 cm renal mass in a 67 year-old female, partial nephrectomy specimen. The tumour is characterized by papillary architecture and cells with abundant granular eosinophilic/oncocytic cytoplasm. The tumour cells have ISUP grade 3 nuclei and cover the papillary fronds generally as a single layer. Many of papillary fronds are distended by foamy histiocytes. The features are those of a papillary renal cell carcinoma with oncocytic features, NOS (neither Type 1 or Type 2 by current convention).