Case ID: 275

Publication date: 05 Jun, 2015

Consensus grade: GS 4+4=8 (ISUP 4)

User Diagnosis Difficulty Comment
Pathologist 1 GS 4+4=8 (ISUP 4) Typical

Cribriform

Pathologist 2 GS 4+4=8 (ISUP 4) Typical
Pathologist 3 GS 4+4=8 (ISUP 4) Typical
Pathologist 4 GS 4+4=8 (ISUP 4) Typical

8 although nuclear atypia is not very high, but these cribriform cases rarely display important atypia

Pathologist 5 GS 4+4=8 (ISUP 4) Typical
Pathologist 6 GS 4+3=7 (ISUP 3) Borderline higher
Pathologist 7 GS 4+4=8 (ISUP 4) Typical
Pathologist 8 GS 4+4=8 (ISUP 4) Typical
Pathologist 9 GS 4+4=8 (ISUP 4) Typical
Pathologist 10 GS 4+4=8 (ISUP 4) Typical
Pathologist 11 GS 4+4=8 (ISUP 4) Typical
Pathologist 12 GS 4+4=8 (ISUP 4) Typical

IDC?

Pathologist 13 GS 4+4=8 (ISUP 4) Typical
Pathologist 14 GS 4+3=7 (ISUP 3) Borderline higher

a few 3 glands but >5% since whole tumor is tiny

Pathologist 15 GS 4+4=8 (ISUP 4) Typical
Pathologist 16 GS 4+4=8 (ISUP 4) Borderline lower

Straightforward case.

Pathologist 17 GS 4+4=8 (ISUP 4) Typical

All cribriform glands

Pathologist 18 GS 4+4=8 (ISUP 4) Borderline lower

or is this all intraductal!!

Pathologist 19 GS 4+4=8 (ISUP 4) Typical
Pathologist 20 GS 4+4=8 (ISUP 4) Typical
Pathologist 21 GS 4+4=8 (ISUP 4) Typical
Pathologist 22 GS 4+4=8 (ISUP 4) Typical
Pathologist 23 GS 4+4=8 (ISUP 4) Typical
Pathologist 24 GS 4+4=8 (ISUP 4) Typical


Case description (by case creator):

Most of the glands in this 448 are cribriform but some are fused. As always it is difficult to know if some of the cribriform glands may be IDC but there is no doubt that there is an invasive component of GP4 here anyway.