Case ID: 1290

Publication date: 05 Feb, 2016

Consensus grade: GS 4+4=8 (ISUP 4)

User Diagnosis Difficulty Comment
Pathologist 1 GS 4+4=8 (ISUP 4) Typical
Pathologist 2 GS 4+3=7 (ISUP 3) Borderline higher

enough 3 to be included as 2nd pattern

Pathologist 3 GS 4+4=8 (ISUP 4) Typical
Pathologist 4 GS 4+4=8 (ISUP 4) Borderline higher

There are rare single separate well-formed glands of pattern 3, but these are less than 5% of the tumor, so 4+4=8/10

Pathologist 5 GS 4+3=7 (ISUP 3) Borderline higher
Pathologist 6 GS 4+4=8 (ISUP 4) Borderline lower
Pathologist 7 GS 4+3=7 (ISUP 3) Typical
Pathologist 8 GS 4+4=8 (ISUP 4) Typical
Pathologist 9 GS 4+3=7 (ISUP 3) Borderline higher
Pathologist 10 GS 4+4=8 (ISUP 4) Typical
Pathologist 11 GS 4+4=8 (ISUP 4) Typical
Pathologist 12 GS 4+4=8 (ISUP 4) Typical
Pathologist 13 GS 4+4=8 (ISUP 4) Typical

<5% pattern 3

Pathologist 14 GS 4+4=8 (ISUP 4) Typical
Pathologist 15 GS 4+4=8 (ISUP 4) Borderline higher
Pathologist 16 GS 4+4=8 (ISUP 4) Typical
Pathologist 17 GS 4+4=8 (ISUP 4) Typical
Pathologist 18 GS 4+3=7 (ISUP 3) Borderline higher
Pathologist 19 GS 4+3=7 (ISUP 3) Borderline higher
Pathologist 20 GS 4+4=8 (ISUP 4) Typical

All cribriform glands and thick-walled glands, a few fused, consistent with Gleason 4+4.

Pathologist 21 GS 4+4=8 (ISUP 4) Borderline lower
Pathologist 22 GS 4+4=8 (ISUP 4) Typical
Pathologist 23 GS 4+4=8 (ISUP 4) Typical


Case description (by case creator):