Case ID: 108

Publication date: 29 May, 2015

Consensus grade: GS 3+3=6 (ISUP 1)

User Diagnosis Difficulty Comment
Pathologist 1 GS 3+3=6 (ISUP 1) Typical
Pathologist 2 GS 3+3=6 (ISUP 1) Typical
Pathologist 3 GS 3+3=6 (ISUP 1) Typical
Pathologist 4 GS 3+3=6 (ISUP 1) Borderline higher
Pathologist 5 GS 3+3=6 (ISUP 1) Typical
Pathologist 6 GS 3+3=6 (ISUP 1) Typical

there are some back to back glands, but I would not consider them as cribriform

Pathologist 7 GS 3+3=6 (ISUP 1) Typical
Pathologist 8 GS 3+4=7 (ISUP 2) Typical
Pathologist 9 GS 3+3=6 (ISUP 1) Borderline higher
Pathologist 10 GS 3+4=7 (ISUP 2) Borderline lower

Possible tangential sectioning and the apparently fused small acini adjacent to the nerve. I would need to see three levels to decide on my best Gleason value. I do not typically call fused acini around a nerve pattern 4

Pathologist 11 GS 3+3=6 (ISUP 1) Typical

A couple of foci suggestive, but not quite good enough for definite pattern 4.

Pathologist 12 GS 3+4=7 (ISUP 2) Borderline lower
Pathologist 13 GS 3+4=7 (ISUP 2) Borderline lower
Pathologist 14 GS 3+3=6 (ISUP 1) Borderline higher
Pathologist 15 GS 3+3=6 (ISUP 1) Borderline higher
Pathologist 16 GS 3+3=6 (ISUP 1) Borderline lower
Pathologist 17 GS 3+3=6 (ISUP 1) Typical

well-formed separate glands

Pathologist 18 GS 3+3=6 (ISUP 1) Typical
Pathologist 19 GS 3+3=6 (ISUP 1) Borderline higher
Pathologist 20 GS 3+3=6 (ISUP 1) Typical
Pathologist 21 GS 3+3=6 (ISUP 1) Borderline higher
Pathologist 22 GS 3+3=6 (ISUP 1) Typical
Pathologist 23 GS 3+4=7 (ISUP 2) Borderline lower
Pathologist 24 GS 3+3=6 (ISUP 1) Borderline higher


Case description (by case creator):

3+3=6 with an occasional seemingly fused gland that may be a tangential cut.