{"id":2813,"date":"2025-01-03T23:24:24","date_gmt":"2025-01-03T23:24:24","guid":{"rendered":"https:\/\/isupimagebase.com\/isup\/?post_type=journal-club&p=2813"},"modified":"2025-01-04T01:17:28","modified_gmt":"2025-01-04T01:17:28","slug":"fourth-quarter-of-2024-3rd-quarter-had-no-articles","status":"publish","type":"journal-club","link":"https:\/\/isupimagebase.com\/isup\/blog\/journal-club\/fourth-quarter-of-2024-3rd-quarter-had-no-articles\/","title":{"rendered":"FOURTH QUARTER OF 2024 (3rd quarter had no articles)"},"content":{"rendered":"\n

Clear Cell Carcinomas of Müllerian Type and Rete Testis Origin Presenting as Scrotal Masses. A Study of Seven Cases, <\/strong>The American Journal of Surgical Pathology. 48:1530-1542, 2024.PMID: 38990735 DOI: 10.1097\/PAS.0000000000002287<\/p>\n

FREE LINK<\/strong> https:\/\/journals.lww.com\/ajsp\/fulltext\/2024\/12000\/clear_cell_carcinomas_of_m_llerian_type_and_rete.6.aspx<\/p>\n

Irem Kilic, Andrés M. Acosta, Thomas M. Ulbright<\/p>\n

Reviewer: Francesca Sanguedolce, MD<\/p>\n

Précis<\/u><\/p>\n

The authors analyzed seven cases of rare clear cell carcinomas (CCC) involving the testis and paratestis. Four were classified as Müllerian-type CCCs (MTCCC), arising in the paratestis or seminal vesicle, while three were identified as papillary CCCs of rete testis origin (RTCCC). MTCCCs exhibited features similar to ovarian and endometrial CCCs, with morphological patterns such as glands, tubules, papillae, and solid nests of clear cells, and showed aggressive behavior with frequent metastases, often involving retroperitoneal lymph nodes, lungs, and bones. RTCCCs were confined to the tubular system of the testis (rete testis and seminiferous tubules), showed branching fibrous papillae with clear or eosinophilic cells (yet lacking hobnail cells), and had a more indolent course with no metastases in the cases studied. Immunohistochemical studies demonstrated an overlapping profile in the two subtypes regarding some markers (i.e., positivity for PAX8, AMACR, napsin A, CK7, and wild-type p53 expression) and distinct for others, as MTCCCs are positive for CA125, while RTCCCs lack CA125 expression and are also positive for CAIX and CD10.<\/p>\n

<\/p>\n

Comment<\/p>\n

In the context of genitourinary tumors, CCCs of Müllerian type have been described as separate entities in the testicular adnexa and the urinary tract, with overlapping clinical features (aggressive course) and immunophenotypic characteristics (positivity for PAX8 and negativity for CAIX). The pathogenesis of these tumors remains speculative, and could be clarified through molecular studies on larger case series. This study, in addition to adding further cases of CCCs to the very few reported in the literature, introduces a new subtype of RTCCC developing within the rete testis, with a more indolent clinical course and an immunohistochemical profile similar to renal neoplasms. This may represent a diagnostic issue: among testicular metastases from solid tumors, those of renal origin are relatively common, and, in one-third of cases, may represent the first clinical manifestation of the disease, according to a recent review [10.3390\/jcm12175636]. While acknowledging the limitations of the small number of cases and the retrospective nature of the study—both inherent to the rarity of such entities—the authors underscore the diagnostic and clinical significance of classifying CCCs of Müllerian type and rete testis origin into two subtypes with distinct prognostic and potentially therapeutic implications.<\/p>\n

NOTE: The authors have no comment to add on this review<\/p>\n<\/body><\/html>\n","protected":false},"excerpt":{"rendered":"

Clear Cell Carcinomas of Müllerian Type and Rete Testis Origin Presenting as Scrotal Masses. A Study of Seven Cases, The American Journal of Surgical Pathology. 48:1530-1542, 2024.PMID: 38990735 DOI: 10.1097\/PAS.0000000000002287 FREE LINK https:\/\/journals.lww.com\/ajsp\/fulltext\/2024\/12000\/clear_cell_carcinomas_of_m_llerian_type_and_rete.6.aspx Irem Kilic, Andrés M. Acosta, Thomas M. Ulbright Reviewer: Francesca Sanguedolce, MD Précis The authors analyzed seven cases of rare clear cell … Continue reading FOURTH QUARTER OF 2024 (3rd quarter had no articles)<\/span> →<\/span><\/a><\/p>\n","protected":false},"featured_media":0,"parent":0,"menu_order":0,"template":"","class_list":["post-2813","journal-club","type-journal-club","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/isupimagebase.com\/isup\/wp-json\/wp\/v2\/journal-club\/2813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/isupimagebase.com\/isup\/wp-json\/wp\/v2\/journal-club"}],"about":[{"href":"https:\/\/isupimagebase.com\/isup\/wp-json\/wp\/v2\/types\/journal-club"}],"wp:attachment":[{"href":"https:\/\/isupimagebase.com\/isup\/wp-json\/wp\/v2\/media?parent=2813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}