Case ID: 427

Publication date: 05 Jan, 2016

Consensus grade: Renal cell carcinoma with leiomyomatous stroma

User Diagnosis Difficulty Comment
Pathologist 1 Renal cell carcinoma with leiomyomatous stroma Not typical
Pathologist 2 Renal cell carcinoma with leiomyomatous stroma Typical

Could be TSC or TCEB-mutated

Pathologist 3 Clear cell RCC Not typical
Pathologist 4 Clear cell tubulopapillary RCC Typical
Pathologist 5 Renal cell carcinoma with leiomyomatous stroma Typical

Differential includes TCEB1 mutant RCC

Pathologist 6 Renal cell carcinoma, unclassified Not typical

likely rcc with leiomyomatous stroma but could be clear cell rcc

Pathologist 7 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 8 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 9 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 10 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 11 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 12 Other Not typical
Pathologist 13 MiT Family translocation carcinoma Typical
Pathologist 14 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 15 Renal cell carcinoma with leiomyomatous stroma Typical

Could be with VHL abnormalities (ie "Grawitz type"), TCEB1 mutated OR without mutations in VHL or TCEB1

Pathologist 16 Renal cell carcinoma with leiomyomatous stroma Not typical
Pathologist 17 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 18 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 19 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 20 Renal cell carcinoma with leiomyomatous stroma Typical
Pathologist 21 Renal cell carcinoma with leiomyomatous stroma Typical


Case description (by case creator):

84 y.o. female with a 3. 5 cm mass along with multiple simple cysts in her left kidney. She underwent a partial nephrectomy.