Case ID: 1043
Publication date: 22 Jan, 2016
Consensus grade: Renal cell carcinoma with leiomyomatous stroma
Show diagnosis by expert panel members| User | Diagnosis | Difficulty | Comment |
|---|---|---|---|
| Pathologist 1 | Renal cell carcinoma with leiomyomatous stroma | Not typical | |
| Pathologist 2 | Renal cell carcinoma with leiomyomatous stroma | Typical |
We would for TCEB 1 mutation |
| Pathologist 3 | Renal cell carcinoma, unclassified | Not typical |
Since there is a lot of pink stroma, this is probably thought to be clear cell renal cell carcinoma with leiomyomatous stroma but the photos show a stroma which looks fibrous to me so garden variety clear cell renal cell carcinoma is a better diagnosis for the photos. |
| Pathologist 4 | Clear cell RCC | Not typical | |
| Pathologist 5 | Renal cell carcinoma with leiomyomatous stroma | Not typical | |
| Pathologist 6 | Renal cell carcinoma with leiomyomatous stroma | Not typical | |
| Pathologist 7 | Clear cell RCC | Not typical | |
| Pathologist 8 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 9 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 10 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 11 | Renal cell carcinoma with leiomyomatous stroma | Typical |
hard to be sure the stroma is muscle in these images |
| Pathologist 12 | Clear cell RCC | Typical | |
| Pathologist 13 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 14 | Renal cell carcinoma, unclassified | Not typical | |
| Pathologist 15 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 16 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 17 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 18 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 19 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 20 | Clear cell RCC | Not typical | |
| Pathologist 21 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 22 | Renal cell carcinoma with leiomyomatous stroma | Typical | |
| Pathologist 23 | Clear cell RCC | Typical |
Case description (by case creator):
Kidney tumor, male 62-year-old. Tumor well circumscribed, yellow color with gray strands on gross section. Tumor composed of clear cell elements resembling cells of typical clear cell RCC. Fibroleiomyomatous stroma was prominent. No sarcomatoid changes were present.
Tumor is positive for CK 7, vimentin. Using next generation sequencing, no abnormalities of VHL gene (methylation, mutation, LOH3p) and TCEB1 gene were disclosed.
Dg: Renal cell carcinoma with (fibro)leiomyomatous stroma
